PT-141

Unit Quantity: 1 vial
Unit Size: 10 mg lyophilized PT-141
Purity (HPLC): 99%
Molar mass: 1,025.2 g/mol
Formula: C50H68N14O10
Elimination half-life: 2.7 hours

PT-141 is a synthetic peptide analog of alpha melanocyte-stimulating hormone (α-MSH), an endogenous neuropeptide best known for its role in stimulating melanogenesis, or the production of melanin.

A non-selective agonist of the melanocortin receptors, PT-141 binds notably to the melanocortin 3 and 4 receptors (MC3R, MC4R), which link to the modulation of sexual behavior and appetite [1].

Extensive clinical research has shown that PT-141′s activity at MC3R and MC4R increases sexual desire in women with hypoactive sexual desire disorder (HSDD), a fairly common disorder that is characterized by a low or lack of sex drive in women [1, 2, 3].

As a melanocortin receptor agonist, PT-141 initiates a physiological response in the subject upon making contact with the melanocortin receptors, located primarily in the midbrain. Both melanocortin receptors 3 and 4 are believed to play a key role in sexual desire and arousal in both males and females [1, 4].

PT-141 is believed to stimulate dopamine hormones that are linked to increased sexual desire; in men, this results in penile erection [6]. This mechanism may be considered advantageous to that of traditional erectile dysfunction (ED) treatments, such as Viagra, which are vasodilators that directly increase blood flow to the penis but require sexual arousal and stimulation to take effect [7].

In the case of women, PT-141 is also thought to work primarily through its activity at MC3R and MC4R, thus triggering the release of dopamine and increasing sexual desire [3, 5]. Prior to the clinical use of PT-141 in women, the treatment of HSDD often included psychosocial and biological treatments, requiring consistent daily or weekly treatments. Fortunately, PT-141 can be taken on an as-needed basis, approximately 45 minutes prior to sexual activity via subcutaneous injection [2, 8].

PT-141 is therefore seen as a convenient treatment that does not require a long-term commitment.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Naltrexone

PT-141 is currently FDA-approved as a naturally safe way to treat erectile dysfunction and female sexual dysfunction.[9] In addition, since it works through the nervous system instead of the cardiovascular system, PT-141 can be administered to most adults and even patients suffering from heart complications.

Use of bremelanotide may produce some side effects, such as headaches (rare), nausea (common), and flushing (common), with varying levels of intensity, ranging from mild to moderate. It may also cause itchiness, and pain on the injection site.

When compared to other similar treatments, the less common side effects of PT-141 are generally considered to be less severe. For example, medications like Viagra have been associated with more serious side effects like heart attack and stroke. In contrast, the less common side effects of PT-141 are generally well-tolerated and limited to mild to moderate symptoms like nausea and dizziness (rare).[4]

Store lyophilizate away from heat, moisture and light between 20°C to 25°C. Once reconstituted keep the solution refrigerated between 2°C to 8°C. Keep all medicine out of the reach of children. Throw away any unused vials after expiration date.